Ingredients / Lion's Mane
Ingredient · 01 of 20

Lion's Mane.

The flagship nootropic mushroom — used for centuries in traditional Asian medicine, now recognised for stimulating Nerve Growth Factor (NGF) and supporting neuroprotection. The cornerstone of the Sharper Human stack.

Lion's Mane mushroom (Hericium erinaceus)
Dose · in stack 1000 mg5:1 Extract
Source Hericium erinaceus 5:1 Extract
Classification Adaptogenic Mushroom
In Sharper Human 20-ingredient stack
01 — What it is

What is Lion's Mane Mushroom?

Lion's Mane mushroom (Hericium erinaceus) is a fascinating fungus that has been used for centuries in traditional medicine, particularly in Asian countries [1]. This unique mushroom — known for its shaggy appearance resembling a lion's mane — has recently gained significant attention in the world of nootropics for its potential cognitive-enhancing and neuroprotective properties [2].

Lion's Mane is an edible mushroom native to North America, Europe, and Asia. It's known by various names including yamabushitake, bearded tooth fungus, and satyr's beard [3].

Historically, Lion's Mane has been used in traditional Chinese medicine for centuries, valued for its potential to support cognitive function and overall health. It was often reserved for royalty and was said to confer "nerves of steel and the memory of a lion." [4]

02 — The Science

The science behind Lion's Mane.

The key to Lion's Mane's effects lies in its bioactive compounds, primarily hericenones and erinacines [5].

  1. Nerve Growth Factor (NGF) stimulation — One of the most exciting properties of Lion's Mane is its potential to stimulate the production of NGF, crucial for the growth, maintenance, and survival of neurons [6].
  2. Cognitive function — A small study in older adults with mild cognitive impairment found that Lion's Mane supplementation improved cognitive function scores [7].
  3. Neuroprotection — Research indicates Lion's Mane may have neuroprotective properties, potentially reducing the risk of neurodegenerative diseases like Alzheimer's and Parkinson's [8].
  4. Mood and anxiety — A study in menopausal women found that Lion's Mane consumption reduced feelings of irritation and anxiety [9].
  5. Neuroplasticity — Lion's Mane may support neuroplasticity — the brain's ability to form new neural connections [10].
03 — Benefits

Benefits of Lion's Mane.

  1. Cognitive enhancement — Particularly in areas of memory and concentration [11].
  2. NGF stimulation — Unique among nootropics for its potential to support nerve growth factor [12].
  3. Neuroprotection — May help in preventing neurodegenerative diseases [13].
  4. Mood support — Some studies suggest anxiolytic and antidepressant effects [14].
  5. Neuroplasticity — May enhance the brain's ability to form new neural connections [15].
  6. Digestive health — Traditionally used for stomach ailments [16].
  7. Antioxidant effects — Contributes to overall health benefits [17].
04 — Dosage

Dosage and our approach.

Effective dosage varies. Studies use doses from 250 mg to 3 g per day. A study in Phytotherapy Research used 3 g of Lion's Mane powder daily and found improvements in cognitive function scores [18].

For general cognitive support, a typical dose is 500–1000 mg of Lion's Mane extract [19].

Our Approach

1000 mg of 5:1 extract — the highest individual dose in the Sharper Human stack, reflecting Lion's Mane's central role. Focus for decades, not minutes.

Effects are cumulative — most studies involve daily dosing over several weeks or months [20]. Daily, consistent use is key.

05 — Side Effects

Potential side effects.

  1. Gastrointestinal discomfort — Mild upset stomach or nausea when starting [21].
  2. Skin rash — Rare, possibly from allergic reaction.
  3. Blood clotting effects — May affect clotting; consult a healthcare provider if on blood thinners.
  4. Respiratory symptoms — Very rare, possibly from spore allergy.
  5. Interactions with medications — Consult a healthcare professional before starting.
06 — Conclusion

In short.

Lion's Mane is a fascinating medicinal mushroom with a long history of traditional use and a growing body of scientific research supporting its cognitive-enhancing and neuroprotective properties. Its true power lies in long-term benefits for brain health — consistent use over time is key.

← Back to all ingredients